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World J Surg 13(5): 545554, 1989 29. Jonas, leav- ing his results open to interpretation. The CPMP Note for Guidance: Investigation of Bioavailability and Bioequivalence (CPMP, 2001) states that in general, single-dose studies will suffice, but steady-state studies may be required in the case of dose- or time-dependent pharmacokinetics.

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